Ontology highlight
ABSTRACT:
SUBMITTER: Jacinto FV
PROVIDER: S-EPMC4495395 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Genes & development 20150616 12
Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channels that mediate nuclear transport across the nuclear envelope. Recent evidence suggests that several Nups have additional roles in controlling the activation and silencing of developmental genes; however, the mechanistic details of these functions remain poorly understood. Here, we show that depletion of Nup153 in mouse embryonic stem cells (mESCs) ...[more]