Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20.

ABSTRACT: Malignant gliomas are the most common malignant tumors in the central nervous system (CNS). Up to date, the prognosis of glioma is still very poor, effective therapy with less side-effect is very necessary. Herein, we identify a compound named as "331" selectively induced cell death in glioma cells but not in astrocytes. Compound 331 upregulated miR-494 and downregulated CDC20 in glioma cells but not in astrocytes. These results suggest that compound 331 could be a potential drug selectively targeting glioma cells through upregulating miR-494 and downregulating CDC20.

SUBMITTER: Zhang L 

PROVIDER: S-EPMC4495416 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature