Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves.

ABSTRACT:

Background

Axons from the visceral motor neurons (vMNs) project from nuclei in the hindbrain to innervate autonomic ganglia and branchial arch-derived muscles. Although much is known about the events that govern specification of somatic motor neurons, the genetic pathways responsible for the development of vMNs are less well characterized. We know that vMNs, like all motor neurons, depend on sonic hedgehog signaling for their generation. Similarly, the paired-like homeobox 2b (Phox2b) gene, which is expressed in both proliferating progenitors and post-mitotic motor neurons, is essential for the development of vMNs. Given that our previous study identified a novel role for the short stature homeobox 2 (Shox2) gene in the hindbrain, and since SHOX2 has been shown to regulate transcri

SUBMITTER: Rosin JM 

PROVIDER: S-EPMC4495855 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature