Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: a randomized clinical trial.

ABSTRACT:

Importance

Colorectal cancer is a major health burden. Screening is recommended in many countries.

Objective

To estimate the effectiveness of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality in a population-based trial.

Design, setting, and participants

Randomized clinical trial of 100,210 individuals aged 50 to 64 years, identified from the population of Oslo city and Telemark County, Norway. Screening was performed in 1999-2000 (55-64-year age group) and in 2001 (50-54-year age group), with follow-up ending December 31, 2011. Of those selected, 1415 were excluded due to prior colorectal cancer, emigration, or death, and 3 could not be traced in the population registry.

Interventions

Participants randomized to the screening group w

SUBMITTER: Holme O 

PROVIDER: S-EPMC4495882 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature