Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation.

ABSTRACT:

Purpose of review

To review the recent developments in our understanding of endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) function in relation to its role in major histocompatibility complex (MHC) class I peptide presentation and human leukocyte antigen (HLA) class I-associated diseases.

Recent findings

ERAP1 polymorphisms exhibiting loss-of-function have been associated with protection from AS. The aminopeptidase function of ERAP1 optimizes peptides for binding and presentation by MHC class I. Most of the studies have revealed reduced MHC class I expression in situations of reduced ERAP1 function. Under these circumstances, the presented peptides are often N-terminally extended, and cell surface complexes are unstable and fall apart more readily. In contrast, peptides

SUBMITTER: Tran TM 

PROVIDER: S-EPMC4495904 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature