Assessment of ligand binding site predictions in CASP10.

ABSTRACT: The identification of amino acid residues in proteins involved in binding small molecule ligands is an important step for their functional characterization, as the function of a protein often depends on specific interactions with other molecules. The accuracy of computational methods aiming to predict such binding residues was evaluated within the "function prediction (prediction of binding sites, FN)" category of the critical assessment of protein structure prediction (CASP) experiment. In the last edition of the experiment (CASP10), 17 research groups participated in this category, and their predictions were evaluated on 13 prediction targets containing biologically relevant ligands. The results of this experiment indicate that several methods achieved an overall good performance, showin

SUBMITTER: Gallo Cassarino T 

PROVIDER: S-EPMC4495912 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature