Bridging the Two Worlds: A Universal Interface between Enzymatic and DNA Computing Systems.

ABSTRACT: Molecular computing based on enzymes or nucleic acids has attracted a great deal of attention due to the perspectives of controlling living systems in the way we control electronic computers. Enzyme-based computational systems can respond to a great variety of small molecule inputs. They have the advantage of signal amplification and highly specific recognition. DNA computing systems are most often controlled by oligonucleotide inputs/outputs and are capable of sophisticated computing as well as controlling gene expressions. Here, we developed an interface that enables communication of otherwise incompatible nucleic-acid and enzyme-computational systems. The enzymatic system processes small molecules as inputs and produces NADH as an output. The NADH output triggers electrochemical release

SUBMITTER: Mailloux S 

PROVIDER: S-EPMC4495919 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature