Lipopolysaccharide significantly influences the hepatic triglyceride metabolism in growing pigs.

ABSTRACT:

Background

In the practical commercial pig farms, inflammation is a perennial problem, yet most of studies on inflammation are focused on immune response. Actually, inflammation can induce body metabolism disorder which will finally influence animals' growth. In this study, we investigated the effect of acute inflammation on the triglyceride (TG) metabolism in the liver of growing pigs and the possible underlying mechanisms.

Methods

Twelve male growing pigs were randomly divided into two groups, a control group (received saline) and a LPS group (intramuscular injected with 15 μg/kg LPS). Six hours after LPS injection, the pigs were euthanized and sampled. Biochemical indexes, inflammation factors, lipid metabolism related parameters and mitochondrial function were evaluated.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC4495945 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature