Genome Wide Distributions and Functional Characterization of Copy Number Variations between Chinese and Western Pigs.

ABSTRACT: Copy number variations (CNVs) refer to large insertions, deletions and duplications in the genomic structure ranging from one thousand to several million bases in size. Since the development of next generation sequencing technology, several methods have been well built for detection of copy number variations with high credibility and accuracy. Evidence has shown that CNV occurring in gene region could lead to phenotypic changes due to the alteration in gene structure and dosage. However, it still remains unexplored whether CNVs underlie the phenotypic differences between Chinese and Western domestic pigs. Based on the read-depth methods, we investigated copy number variations using 49 individuals derived from both Chinese and Western pig breeds. A total of 3,131 copy number variation regio

SUBMITTER: Wang H 

PROVIDER: S-EPMC4496047 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature