TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation.

ABSTRACT: Neuroblastoma is an embryonal tumor derived from poorly differentiated neural crest cells. Current research is aimed at identifying the molecular mechanisms that maintain the progenitor state of neuroblastoma cells and to develop novel therapeutic strategies that induce neuroblastoma cell differentiation. Mechanisms controlling neural crest development are typically dysregulated during neuroblastoma progression, and provide an appealing starting point for drug target discovery. Transcriptional programs involved in neural crest development act as a context dependent gene regulatory network. In addition to BMP, Wnt and Notch signaling, activation of developmental gene expression programs depends on the physical characteristics of the tissue microenvironment. TRPM7, a mechanically regulated T

SUBMITTER: Middelbeek J 

PROVIDER: S-EPMC4496182 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature