Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer.

ABSTRACT: The clinical significance of Cluster of Differentiation 44 (CD44) remains controversial in human ovarian cancer. The aim of this study is to evaluate the clinical significance of CD44 expression by using a unique tissue microarray, and then to determine the biological functions of CD44 in ovarian cancer. In this study, a unique ovarian cancer tissue microarray (TMA) was constructed with paired primary, metastatic, and recurrent tumor tissues from 26 individual patients. CD44 expression in TMA was assessed by immunohistochemistry. Both the metastatic and recurrent ovarian cancer tissues expressed higher level of CD44 than the patient-matched primary tumor. A significant association has been shown between CD44 expression and both the disease free survival and overall survival. A strong incre

SUBMITTER: Gao Y 

PROVIDER: S-EPMC4496219 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature