Head and neck cancer subtypes with biological and clinical relevance: Meta-analysis of gene-expression data.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is a disease with heterogeneous clinical behavior and response to therapies. Despite the introduction of multimodality treatment, 40-50% of patients with advanced disease recur. Therefore, there is an urgent need to improve the classification beyond the current parameters in clinical use to better stratify patients and the therapeutic approaches. Following a meta-analysis approach we built a large training set to whom we applied a Disease-Specific Genomic Analysis (DSGA) to identify the disease component embedded into the tumor data. Eleven independent microarray datasets were used as validation sets. Six different HNSCC subtypes that summarize the aberrant alterations occurring during tumor progression were identified. Based on their main biol

SUBMITTER: De Cecco L 

PROVIDER: S-EPMC4496244 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature