ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability.

ABSTRACT:

Background

While recent data show that crizotinib is highly effective in patients with ROS1 rearrangement, few data is available about the prognostic impact, the predictive value for different treatments, and the genetic heterogeneity of ROS1-positive patients.

Patients and methods

1137 patients with adenocarcinoma of the lung were analyzed regarding their ROS1 status. In positive cases, next-generation sequencing (NGS) was performed. Clinical characteristics, treatments and outcome of these patients were assessed. Overall survival (OS) was compared with genetically defined subgroups of ROS1-negative patients.

Results

19 patients of 1035 evaluable (1.8%) had ROS1-rearrangement. The median OS has not been reached. Stage IV patients with ROS1-rearrangement had the best

SUBMITTER: Scheffler M 

PROVIDER: S-EPMC4496376 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature