Predictive value of early brain atrophy on response in patients treated with interferon β.

ABSTRACT:

Objective

To investigate the association between brain volume loss during the first year of interferon treatment and clinical outcome at 4 years.

Methods

Patients with multiple sclerosis initiating interferon β were clinically evaluated every 6 months for the presence of relapses and assessment of global disability using the Expanded Disability Status Scale (EDSS). MRI scans were performed at baseline and after 12 months, and the percentage of brain volume change (PBVC), brain parenchymal volume change (BPVc%), gray matter volume change (GMVc%), and white matter volume change (WMVc%) were estimated. Patients were divided based on the cutoff values for predicting confirmed EDSS worsening obtained by receiver operating characteristic analysis for all atrophy measurements. Surv

SUBMITTER: Perez-Miralles FC 

PROVIDER: S-EPMC4496631 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature