AXIN2 rs2240308 polymorphism contributes to increased cancer risk: evidence based on a meta-analysis.

ABSTRACT:

Background

Variants in the axis inhibition 2 (AXIN2) gene might alter the protein's structure or function or create a multiprotein destruction complex in the Wnt signaling pathway and thus affect an individual's susceptibility to cancer. The objective of this study is to evaluate broadly the evidence available for the AXIN2 rs2240308 polymorphism and risk of cancer.

Methods

A comprehensive literature search was undertaken for eligible studies in Embase, PubMed, and Cochrane Library up to Nov 30, 2014. Odds ratios (ORs) and the corresponding 95 % confidence intervals (CIs) were used to measure the strength of the models.

Results

Eight articles (10 case-control studies with 1,502 cases and 1,590 controls) were included in this analysis. Overall, the AXIN2 rs2240308 poly

SUBMITTER: Wu Z 

PROVIDER: S-EPMC4496878 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature