Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon.

ABSTRACT:

Background/aims

Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine the distribution of 5-HT3, 5-HT4, and 5-HT7 receptors in the normal human colon and how this is associated with receptor interacting chaperone 3, G protein coupled receptor kin-ases, and protein LIN-7 homologs to extend previous observations limited to the sigmoid colon or the upper intestine.

Methods

Samples from ascending, transverse, descending, and sigmoid human colon were dissected into 3 separate layers (mucosa, lon-gitudinal, and circular muscles) and ileum samples were dissected into mucosa and muscle layers (n = 20). Complementary DNA was synthesized b

SUBMITTER: Yaakob NS 

PROVIDER: S-EPMC4496915 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature