Predicting N-terminal myristoylation sites in plant proteins.

ABSTRACT:

Background

N-terminal myristoylation plays a vital role in membrane targeting and signal transduction in plant responses to environmental stress. Although N-myristoyltransferase enzymatic function is conserved across plant, animal, and fungal kingdoms, exact substrate specificities vary, making it difficult to predict protein myristoylation accurately within specific taxonomic groups.

Results

A new method for predicting N-terminal myristoylation sites specifically in plants has been developed and statistically tested for sensitivity, specificity, and robustness. Compared to previously available methods, the new model is both more sensitive in detecting known positives, and more selective in avoiding false positives. Scores of myristoylated and non-myristoylated proteins are

SUBMITTER: Podell S 

PROVIDER: S-EPMC449705 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature