OPCML is frequently methylated in human colorectal cancer and its restored expression reverses EMT via downregulation of smad signaling.

ABSTRACT: Emerging evidence has indicated that the expression of OPCML gene is frequently altered in a variety of cancers. We previously demonstrated that the OPCML gene is a target of epigenetic inactivation and its gene product exhibits tumor-suppressive properties. However, little is known regarding the effects and mechanisms of OPCML in colon cancer. We show that the loss or downregulation of OPCML is associated with its promoter hypermethylation. Methylation of the OPCML promoter was detected in all tumors and tumor-adjacent tissues, but lower methylation in normal colon tissues. The drug-induced release of epigenetic silencing was able to restore OPCML expression and the re-expression led to the suppression of cell growth. Furthermore, the increase in OPCML expression reversed a partial epithe

SUBMITTER: Li C 

PROVIDER: S-EPMC4497432 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature