Immunogenicity of single versus mixed allele vaccines of Plasmodium vivax Duffy binding protein region II.

ABSTRACT: The Duffy binding protein (DBP) of Plasmodium vivax is vital for host erythrocyte invasion. DBP region II (DBPII) contains critical residues for receptor recognition and anti-DBPII antibodies have been shown to inhibit erythrocyte binding and invasion, thereby making the molecule an attractive vaccine candidate against P. vivax blood stages. Similar to other blood-stage antigens, allelic variation within the DBPII and associated strain-specific immunity is a major challenge for development of a broadly effective vaccine against P. vivax malaria. We hypothesized that immunization with a vaccine composed of multiple DBP alleles or a modified epitope DBP (DEKnull) will be more effective in producing a broadly reactive and inhibitory antibody response to diverse DBPII alleles than a single all

SUBMITTER: Ntumngia FB 

PROVIDER: S-EPMC4497540 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature