Synthesis and bioactivity of nobilamide B.

ABSTRACT: An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. Z-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons.

SUBMITTER: Jacinto MP 

PROVIDER: S-EPMC4497583 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature