Slowing DNA Transport Using Graphene-DNA Interactions.

ABSTRACT: Slowing down DNA translocation speed in a nanopore is essential to ensuring reliable resolution of individual bases. Thin membrane materials enhance spatial resolution but simultaneously reduce the temporal resolution as the molecules translocate far too quickly. In this study, the effect of exposed graphene layers on the transport dynamics of both single (ssDNA) and double-stranded DNA (dsDNA) through nanopores is examined. Nanopore devices with various combinations of graphene and Al₂O₃ dielectric layers in stacked membrane structures are fabricated. Slow translocations of ssDNA in nanopores drilled in membranes with layers of graphene are reported. The increased hydrophobic interactions between the ssDNA and the graphene layers could explain this phenomenon. Furthe

SUBMITTER: Banerjee S 

PROVIDER: S-EPMC4497588 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature