Progestogen levels, progesterone receptor gene polymorphisms, and mammographic density changes: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study.

ABSTRACT:

Objective

Estrogen plus progestin therapy (EPT) in postmenopausal women increases breast cancer risk and mammographic density to a higher extent than does estrogen therapy alone. Data from the randomized placebo-controlled Postmenopausal Estrogen/Progestinv Interventions trial showed that EPT-induced increases in serum estrone and estrone sulfate levels were positively correlated with increases in mammographic density. Here, after adjusting for serum estrone and estrone sulfate levels, we investigated the roles of posttreatment serum progestogen increase and of progesterone receptor gene (PGR) genetic variations on changes in mammographic density.

Methods

We measured the percent mammographic density and serum progestogen levels in 280 Postmenopausal Estrogen/Progestin Interv

SUBMITTER: Lee E 

PROVIDER: S-EPMC4497814 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature