Pharmacokinetics of anti-TB drugs in Malawian children: reconsidering the role of ethambutol.

ABSTRACT:

Background

Current guidelines for dosing of anti-TB drugs in children advocate higher doses for rifampicin and isoniazid despite limited availability of paediatric data on the pharmacokinetics of these drugs, especially from Africa, where the burden of childhood disease remains high.

Methods

Thirty children aged 6 months to 15 years underwent intensive pharmacokinetic sampling for first-line anti-TB drugs at Queen Elizabeth Central Hospital, Blantyre, Malawi. Rifampicin, isoniazid, pyrazinamide and ethambutol were dosed at 10, 5, 25 and 20 mg/kg, respectively. Plasma drug concentrations were determined using sensitive, validated bioanalytical methods and summary pharmacokinetic parameters were estimated using non-compartmental analysis.

Results

The median (IQR) Cmax w

SUBMITTER: Mlotha R 

PROVIDER: S-EPMC4498297 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature