Structural Organization of Enzymes of the Phenylacetate Catabolic Hybrid Pathway.

ABSTRACT: Aromatic compounds are the second most abundant class of molecules on the earth and frequent environmental pollutants. They are difficult to metabolize due to an inert chemical structure, and of all living organisms, only microbes have evolved biochemical pathways that can open an aromatic ring and catabolize thus formed organic molecules. In bacterial genomes, the phenylacetate (PA) utilization pathway is abundant and represents the central route for degradation of a variety of organic compounds, whose degradation reactions converge at this pathway. The PA pathway is a hybrid pathway and combines the dual features of aerobic metabolism, i.e., usage of both oxygen to open the aromatic ring and of anaerobic metabolism-coenzyme A derivatization of PA. This allows the degradation process to b

SUBMITTER: Grishin AM 

PROVIDER: S-EPMC4498308 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature