Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects.

ABSTRACT:

Background

Maternal air pollution exposure has been related to orofacial clefts but the literature is equivocal. Potential chronic preconception effects have not been studied.

Objectives

Criteria air pollutant exposure during three months preconception and gestational weeks 3-8 was studied in relation to orofacial defects.

Methods

Among 188,102 live births and fetal deaths from the Consortium on Safe Labor (2002-2008), 63 had isolated cleft palate (CP) and 159 had isolated cleft lip with or without cleft palate (CL ±CP). Exposures were estimated using a modified Community Multiscale Air Quality model. Logistic regression with generalized estimating equations adjusted for site/region and maternal demographic, lifestyle and clinical factors calculated the odds ratio (OR

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC4498658 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature