Adaptive evolution and elucidating the potential inhibitor against schizophrenia to target DAOA (G72) isoforms.

ABSTRACT: Schizophrenia (SZ), a chronic mental and heritable disorder characterized by neurophysiological impairment and neuropsychological abnormalities, is strongly associated with D-amino acid oxidase activator (DAOA, G72). Research studies emphasized that overexpression of DAOA may be responsible for improper functioning of neurotransmitters, resulting in neurological disorders like SZ. In the present study, a hybrid approach of comparative modeling and molecular docking followed by inhibitor identification and structure modeling was employed. Screening was performed by two-dimensional similarity search against selected inhibitor, keeping in view the physiochemical properties of the inhibitor. Here, we report an inhibitor compound which showed maximum binding affinity against four selected isofo

SUBMITTER: Sehgal SA 

PROVIDER: S-EPMC4498731 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature