Using Whole Genome Analysis to Examine Recombination across Diverse Sequence Types of Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is an important clinical pathogen worldwide and understanding this organism's phylogeny and, in particular, the role of recombination, is important both to understand the overall spread of virulent lineages and to characterize outbreaks. To further elucidate the phylogeny of S. aureus, 35 diverse strains were sequenced using whole genome sequencing. In addition, 29 publicly available whole genome sequences were included to create a single nucleotide polymorphism (SNP)-based phylogenetic tree encompassing 11 distinct lineages. All strains of a particular sequence type fell into the same clade with clear groupings of the major clonal complexes of CC8, CC5, CC30, CC45 and CC1. Using a novel analysis method, we plotted the homoplasy density and SNP density across the whol

SUBMITTER: Driebe EM 

PROVIDER: S-EPMC4498916 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature