Racial Differences in Natriuretic Peptide Levels: The Dallas Heart Study.

ABSTRACT:

Objectives

The purpose of this study was to assess whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels differ according to race/ethnicity.

Background

Natriuretic peptides (NP) are hormones with natriuretic, diuretic, and vasodilatory effects. Experimental NP deficiency promotes salt-sensitive hypertension and cardiac hypertrophy, conditions that are more common among black individuals.

Methods

We examined plasma NT-proBNP levels according to race/ethnicity in 3,148 individuals (51% black, 31% white, 18% Hispanic) free of prevalent cardiovascular disease in the Dallas Heart Study. NT-proBNP values in the bottom sex-specific quartile were defined as low. Multivariable linear and logistic regression analyses were performed adjusting for clinical covariat

SUBMITTER: Gupta DK 

PROVIDER: S-EPMC4498971 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature