Novel Therapy to Treat Corneal Epithelial Defects: A Hypothesis with Growth Hormone.

ABSTRACT: Impaired corneal wound healing that occurs with ocular surface disease, trauma, systemic disease, or surgical intervention can lead to persistent corneal epithelial defects (PCED), which result in corneal scarring, ulceration, opacification, corneal neovascularization, and, ultimately, visual compromise and vision loss. The current standard of care can include lubricants, ointments, bandage lenses, amniotic membranes, autologous serum eye drops, and corneal transplants. Various inherent problems exist with application and administration of these treatments, which often may not result in a completely healed surface. A topically applicable compound capable of promoting corneal epithelial cell proliferation and/or migration would be ideal to accelerate healing. We hypothesize that human growt

SUBMITTER: Wirostko B 

PROVIDER: S-EPMC4498999 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature