Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment.

ABSTRACT: Cognitive deficits and reduced educational achievement are common in psychiatric illness; understanding the genetic basis of cognitive and educational deficits may be informative about the etiology of psychiatric disorders. A recent, large genome-wide association study (GWAS) reported a genome-wide significant locus for years of education, which subsequently demonstrated association to general cognitive ability ("g") in overlapping cohorts. The current study was designed to test whether GWAS hits for educational attainment are involved in general cognitive ability in an independent, large-scale collection of cohorts. Using cohorts in the Cognitive Genomics Consortium (COGENT; up to 20,495 healthy individuals), we examined the relationship between g and variants associated with educational

SUBMITTER: Trampush JW 

PROVIDER: S-EPMC4500051 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature