Marginally hydrophobic transmembrane α-helices shaping membrane protein folding.

ABSTRACT: Cells have developed an incredible machinery to facilitate the insertion of membrane proteins into the membrane. While we have a fairly good understanding of the mechanism and determinants of membrane integration, more data is needed to understand the insertion of membrane proteins with more complex insertion and folding pathways. This review will focus on marginally hydrophobic transmembrane helices and their influence on membrane protein folding. These weakly hydrophobic transmembrane segments are by themselves not recognized by the translocon and therefore rely on local sequence context for membrane integration. How can such segments reside within the membrane? We will discuss this in the light of features found in the protein itself as well as the environment it resides in. Several cha

SUBMITTER: De Marothy MT 

PROVIDER: S-EPMC4500307 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature