Serum Alkaline Phosphatase and Risk of Incident Cardiovascular Disease: Interrelationship with High Sensitivity C-Reactive Protein.

ABSTRACT:

Background

Alkaline phosphatase (ALP) has been suggested to be associated with cardiovascular disease (CVD) risk, however, important aspects of the association, such as shape and independence from established risk factors, have yet to be characterized in detail. We assessed the association of ALP with CVD risk and determined its utility for CVD risk prediction.

Methods

Alkaline phosphatase activity was measured at baseline in the PREVEND prospective cohort involving 6,974 participants aged 28-75 years without pre-existing CVD. Hazard ratios (95% confidence intervals [CI]) and measures of risk discrimination and reclassification were assessed.

Results

During a median follow-up of 10.5 years, 737 participants developed CVD. Serum ALP was correlated with several risk mar

SUBMITTER: Kunutsor SK 

PROVIDER: S-EPMC4500413 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature