Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson's Disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is diagnosed based upon medical history, neuropsychiatric examination, cerebrospinal fluid analysis, extensive laboratory analyses and cerebral imaging. Diagnosis is time consuming and labour intensive. Parkinson's disease (PD) is mainly diagnosed on clinical grounds.

Objective

The primary aim of this study was to differentiate patients suffering from AD, PD and healthy controls by investigating exhaled air with the electronic nose technique. After demonstrating a difference between the three groups the secondary aim was the identification of specific substances responsible for the difference(s) using ion mobility spectroscopy. Thirdly we analysed whether amyloid beta (Aβ) in exhaled breath was causative for the observed differences betwee

SUBMITTER: Bach JP 

PROVIDER: S-EPMC4500505 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature