Association Between Endogenous Sex Hormones and Liver Fat in a Multiethnic Study of Atherosclerosis.

ABSTRACT:

Background & aims

Levels of circulating of sex hormones are associated with glucose metabolism and adiposity, but little is known about their association with ectopic fat. We aimed to characterize the association between circulating sex hormones and liver fat.

Methods

We conducted a cross-sectional analysis by using data from the Multiethnic Study of Atherosclerosis to assess the association of the circulating levels of bioavailable testosterone, estradiol, dehydroepiandrosterone, and sex hormone binding globulin (SHBG) with fatty liver. Fatty liver was defined as a reduction of ≤40 Hounsfield units, measured by computed tomography, in 2835 postmenopausal women and 2899 men (45-84 years old; white, black, Hispanic, or Chinese) at 6 centers in the United States.

Results

SUBMITTER: Lazo M 

PROVIDER: S-EPMC4500744 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature