Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C.

ABSTRACT: The procedures for the synthesis of esters of dehydropeptides containing C-terminal (Z)-dehydrophenylalanine and dehydroalanine have been elaborated. These esters appeared to be moderate or weak inhibitors of cathepsin C, with some of them exhibiting slow-binding behavior. As shown by molecular modeling, they are rather bound at the surface of the enzyme and are not submersed in its binding cavities.

SUBMITTER: Makowski M 

PROVIDER: S-EPMC4500854 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature