Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review.

ABSTRACT:

Background

Increased bioavailability of phenylephrine is reported when combined with paracetamol in over-the-counter formulations for the symptomatic treatment of the common cold and influenza. Such formulations could increase phenylephrine-related cardiovascular adverse events particularly in susceptible individuals. Quantification of the effect of phenylephrine concentration on blood pressure allows simulation of potential adverse combination therapy effects.

Methods

MEDLINE and EMBASE databases were searched for papers discussing or describing any adverse effect, hypersensitivity or safety concerns related to phenylephrine alone or in combination with other drugs. The pharmacodynamic relationship between plasma phenylephrine concentration and mean arterial blood pressure

SUBMITTER: Atkinson HC 

PROVIDER: S-EPMC4500855 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature