Broad protection with an inactivated vaccine against primary-isolated lethal enterovirus 71 infection in newborn mice.

ABSTRACT:

Background

Circulating enterovirus 71 (EV-A71)-associated hand, foot, and mouth disease is on the rise in the Asian-Pacific region. Although animal models have been developed using mouse-adapted EV-A71 strains, mouse models using primary EV-A71 isolates are scarce. Lethal animal models with circulating EV-A71 infection would contribute to studies of pathogenesis as well as vaccine development and evaluation.

Results

In this study, we established a lethal mouse model using primary EV-A71 isolates from patients infected with serotypes that are currently circulating in humans. We also characterized the dose-dependent virulence and pathologic changes of circulating EV-A71 in this mouse model. Most importantly, we have established this mouse model as a suitable system for EV-A71

SUBMITTER: Chang J 

PROVIDER: S-EPMC4501189 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature