Identification of two novel mammographic density loci at 6Q25.1.

ABSTRACT:

Introduction

Mammographic density (MD) is a strong heritable and intermediate phenotype for breast cancer, but much of its genetic variation remains unexplained. We performed a large-scale genetic association study including 8,419 women of European ancestry to identify MD loci.

Methods

Participants of three Swedish studies were genotyped on a custom Illumina iSelect genotyping array and percent and absolute mammographic density were ascertained using semiautomated and fully automated methods from film and digital mammograms. Linear regression analysis was used to test for SNP-MD associations, adjusting for age, body mass index, menopausal status and six principal components. Meta-analyses were performed by combining P values taking sample size, study-specific inflation facto

SUBMITTER: Brand JS 

PROVIDER: S-EPMC4501298 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature