Outcomes associated with invasive and noninvasive ventilation among patients hospitalized with exacerbations of chronic obstructive pulmonary disease.

ABSTRACT:

Importance

Small clinical trials have shown that noninvasive ventilation (NIV) is efficacious in reducing the need for intubation and improving short-term survival among patients with severe exacerbations of chronic obstructive pulmonary disease (COPD). Little is known, however, about the effectiveness of NIV in routine clinical practice.

Objective

To compare the outcomes of patients with COPD treated with NIV to those treated with invasive mechanical ventilation (IMV).

Design, setting, and participants

This was a retrospective cohort study of 25 628 patients hospitalized for exacerbation of COPD who received mechanical ventilation on the first or second hospital day at 420 US hospitals participating in the Premier Inpatient Database.

Exposures

Initial ventilat

SUBMITTER: Lindenauer PK 

PROVIDER: S-EPMC4501470 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature