A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache.

ABSTRACT:

Objective

To compare the effectiveness and side effects of migraine prophylactic medications.

Design

We performed a network meta-analysis. Data were extracted independently in duplicate and quality was assessed using both the JADAD and Cochrane Risk of Bias instruments. Data were pooled and network meta-analysis performed using random effects models.

Data sources

PUBMED, EMBASE, Cochrane Trial Registry, bibliography of retrieved articles through 18 May 2014.

Eligibility criteria for selecting studies

We included randomized controlled trials of adults with migraine headaches of at least 4 weeks in duration.

Results

Placebo controlled trials included alpha blockers (n = 9), angiotensin converting enzyme inhibitors (n = 3), angiotensin receptor blockers (n

SUBMITTER: Jackson JL 

PROVIDER: S-EPMC4501738 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature