Clinical Features of Alzheimer Disease With and Without Lewy Bodies.

ABSTRACT:

Importance

Lewy bodies are a frequent coexisting pathology in late-onset Alzheimer disease (AD). Previous studies have examined the contribution of Lewy bodies to the clinical phenotype of late-onset AD with variable findings.

Objective

To determine whether the presence of Lewy body pathology influences the clinical phenotype and progression of symptoms in longitudinally assessed participants with AD.

Design, setting, and participants

Retrospective clinical and pathological cohort study of 531 deceased participants who met the neuropathologic criteria for intermediate or high likelihood of AD according to the National Institute on Aging-Ronald Reagan Institute guidelines for the neuropathologic diagnosis of AD. All participants had a clinical assessment within 2 years

SUBMITTER: Chung EJ 

PROVIDER: S-EPMC4501861 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature