Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers.

ABSTRACT:

Objective

We aimed to determine whether there was a relationship between lifestyle factors and Alzheimer disease biomarkers.

Methods

In a cross-sectional study, we evaluated self-reported histories of recent and past cognitive activity, self-reported history of recent physical activity, and objective recent walking activity in 186 clinically normal individuals with mean age of 74 ± 6 years. Using backward elimination general linear models, we tested the hypotheses that greater cognitive or physical activity would be associated with lower Pittsburgh compound B-PET retention, greater (18)F-fluorodeoxyglucose-PET metabolism, and larger hippocampal volume, as well as better cognitive performance on neuropsychological testing.

Results

Linear regression demonstrated that hi

SUBMITTER: Gidicsin CM 

PROVIDER: S-EPMC4501938 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature