Design and synthesis of active heparan sulfate-based probes.

ABSTRACT: A chemoenzymatic approach for synthesizing heparan sulfate oligosaccharides with a reactive diazoacetyl saccharide residue is reported. The resultant oligosaccharides were demonstrated to serve as specific inhibitors for heparan sulfate sulfotransferases, offering a new set of tools to probe the structural selectivity for heparan sulfate-binding proteins.

SUBMITTER: Zhou W 

PROVIDER: S-EPMC4502442 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature