Body fatness during childhood and adolescence and breast density in young women: a prospective analysis.

ABSTRACT:

Introduction

Overweight and obesity in childhood and adolescence are associated with reduced breast cancer risk, independent of adult body mass index (BMI). These associations may be mediated through breast density.

Methods

We prospectively examined associations of early life body fatness with adult breast density measured by MRI in 182 women in the Dietary Intervention Study in Children (DISC) who were ages 25-29 at follow-up. Height, weight, and other factors were measured at baseline (ages 8-10) and annual clinic visits through adolescence. We used linear mixed-effects models to quantify associations of percent breast density and dense and non-dense breast volume at ages 25-29 with quartiles of age-specific youth body mass index (BMI) Z-scores, adjusting for clinic, treat

SUBMITTER: Bertrand KA 

PROVIDER: S-EPMC4502611 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature