Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.
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ABSTRACT:
SUBMITTER: Ulbricht A
PROVIDER: S-EPMC4502687 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.
Ulbricht Anna A Gehlert Sebastian S Leciejewski Barbara B Schiffer Thorsten T Bloch Wilhelm W Höhfeld Jörg J
Autophagy 20150101 3
Chaperone-assisted selective autophagy (CASA) is a tension-induced degradation pathway essential for muscle maintenance. Impairment of CASA causes childhood muscle dystrophy and cardiomyopathy. However, the importance of CASA for muscle function in healthy individuals has remained elusive so far. Here we describe the impact of strength training on CASA in a group of healthy and moderately trained men. We show that strenuous resistance exercise causes an acute induction of CASA in affected muscle ...[more]
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