Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles.

ABSTRACT: The direct arylation of benzo[b]furan, benzo[b]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2-position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo-fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[b]furan.

SUBMITTER: Dao-Huy T 

PROVIDER: S-EPMC4502765 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature