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Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.

ABSTRACT: To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular clockworks.

SUBMITTER: Jones JR 

PROVIDER: S-EPMC4502919 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.

Jones Jeff R JR   Tackenberg Michael C MC   McMahon Douglas G DG  

Nature neuroscience 20150202 3

To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular cloc  ...[more]

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