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A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.


ABSTRACT: Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self-regulation to be managed by a single operator.

SUBMITTER: Ingham RJ 

PROVIDER: S-EPMC4502965 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.

Ingham Richard J RJ   Battilocchio Claudio C   Fitzpatrick Daniel E DE   Sliwinski Eric E   Hawkins Joel M JM   Ley Steven V SV  

Angewandte Chemie (International ed. in English) 20141105 1


Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising  ...[more]

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