Activated platelet-T-cell conjugates in peripheral blood of patients with HIV infection: coupling coagulation/inflammation and T cells.

ABSTRACT:

Background

Despite successfully suppressed viremia by treatment, patients with high levels of biomarkers of coagulation/inflammation are at an increased risk of developing non-AIDS defining serious illnesses such as cardiovascular diseases. Thus, there is a relationship between persistent immune activation and coagulation/inflammation, although the mechanisms are poorly understood. Platelets play an important role in this process. Although interactions between platelets and elements of the innate immune system, such as monocytes, are well described, little is known about the interaction between platelets and the adaptive immune system.

Design

We investigated the interaction of a component of the coagulation system, platelets, and the adaptive immune system T cells.

Method

SUBMITTER: Green SA 

PROVIDER: S-EPMC4502988 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature