Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair.

ABSTRACT:

Objectives

Post-operative stiffness is common after rotator cuff repair, given the difference in susceptibility and severity, the genetic factors may be involved. Interleukin 6 (IL-6) and Matrix metalloproteinases 3 (MMP-3) were previous found as key cytokines in the pathologies of adhesive capsulitis. The present study aims to investigate whether variants within the IL-6 and MMP-3 gene contributed to post-operative stiffness in a Chinese Han population.

Methods

A total of 188 patients diagnosed with rotator cuff tears treated with mini-open surgery were enrolled in this study, among which 87 patients were diagnosed as post-operative stiffness and the remaining 101 patients as controls. All subjects were genotyped for IL-6 and MMP-3 SNPs.

Results

The rs1800796 of IL-6

SUBMITTER: Ling Y 

PROVIDER: S-EPMC4503156 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature